|本期目录/Table of Contents|

[1]訾娅鑫,雷金凤,徐志朗,等.多糖的氧化改性及在生物医药领域的应用[J].生物加工过程,2018,16(01):31-37.[doi:10.3969/j.issn.1672-3678.2018.01.004]
 ZI Yaxin,LEI Jinfeng,XU Zhilang,et al.Preparation and biomedical applications of oxidized polysaccharides[J].Chinese Journal of Bioprocess Engineering,2018,16(01):31-37.[doi:10.3969/j.issn.1672-3678.2018.01.004]
点击复制

多糖的氧化改性及在生物医药领域的应用()
分享到:

《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
16
期数:
2018年01期
页码:
31-37
栏目:
出版日期:
2018-01-30

文章信息/Info

Title:
Preparation and biomedical applications of oxidized polysaccharides
文章编号:
1672-3678(2018)01-0031-07
作者:
訾娅鑫雷金凤徐志朗李德富穆畅道
四川大学 化学工程学院,四川 成都 610065
Author(s):
ZI YaxinLEI JinfengXU ZhilangLI DefuMU Changdao
School of Chemical Engineering,Sichuan University,Chengdu 610065,China
关键词:
氧化多糖 交联剂 包合物 抗菌剂
分类号:
Q539
DOI:
10.3969/j.issn.1672-3678.2018.01.004
文献标志码:
A
摘要:
氧化是多糖化学改性中最为简单和广泛应用的方法之一,它将多糖的大量羟基转变为醛基或羧基,并赋予多糖许多理想的性能。氧化多糖已被广泛应用于食品、医药和化工等领域。本文中,笔者介绍了以高碘酸盐、次氯酸钠和过氧化氢为氧化剂制备氧化多糖的机制与条件,探讨了氧化对多糖分子结构和物化性能的影响。最后,对氧化多糖在蛋白基生物材料交联剂、包合物制备和新型抗菌剂等生物医药领域的应用进行了介绍。

参考文献/References:

[1] REDDY K,KRISHNA MOHAN G,SATLA S,et al.Natural polysaccharides:versatile excipients for controlled drug delivery systems[J].Asian J Pharm Sci,2011,6(6):275-286.
[2] YANG J,XIE Y,HE W.Research progress on chemical modification of alginate:a review[J].Carbohydr Polym,2011,84:33-39.
[3] D’AYALA G G,MALINCONICO M,LAURIENZO P.Marine derived polysaccharides for biomedical applications:chemical modification approaches[J].Molecules,2008,13(9):2069-2106.
[4] 董群,方积年.多糖在医药领域中的应用[J].中国药学杂志,2001,36(10):649-652.
[5] 王松涛,张静,林晓,等.一种基于乳糖与糊化淀粉的新型共处理辅料研究[J].中国中药杂志,2014,39(22):4329-4334.
[6] 张莉华,李科,卜方方.海藻酸钠在药物制剂中的应用进展[J].中南药学,2016,14(1):52-56.
[7] 袁超,桑璐媛,刘亚伟.k-卡拉胶的功能特性及其应用研究进展[J].河南工业大学学报(自然科学版),2016,37(4):118-123.
[8] 邓乐君,樊鸿浩,李伟达,等.可吸收止血材料的生物相容性研究进展[J].中国生物医学工程学报,2016,35(2):241-246.
[9] SONG L,SANG Y,CAI L,et al.The effect of cooking on the antibacterial activity of the dialdehyde starch suspensions[J].Starch-St?rke,2010,62(9):458-466.
[10] KRISTIANSEN K A,POTTHAST A,CHRISTENSEN B E.Periodate oxidation of polysaccharides for modification of chemical and physical properties[J].Carbohydr Res,2010,345(10):1264-1271.
[11] 王琴梅,张亦霞,李卓萍,等.多醛基海藻酸钠交联剂的制备及性能[J].应用化学,2010,27(2):155-158.
[12] 朱颖,刘文杰,左迎峰,等.双醛淀粉酸解氧化制备工艺优化研究[J].西南林业大学学报,2017,37(3):199-203.
[13] 杨扬,刘金刚,苏艳群.利用高碘酸钠选择性氧化阔叶木浆[J].中国造纸,2015,34(4):16-21.
[14] LI H,WU B,MU C,et al.Concomitant degradation in periodate oxidation of carboxymethyl cellulose[J].Carbohydr Polym,2011,84:881-886.
[15] VANIER N L,EL HALAL S L M,DIAS A R G,et al.Molecular structure,functionality and applications of oxidized starches:a review[J].Food Chem,2017,221:1546-1559.
[16] 李德富,李宏利,林炜,等.改性淀粉的制备与应用研究进展[J].中国皮革,2007,36(1):32-37.
[17] SAITO T,ISOGAI A.TEMPO-mediated oxidation of native cellulose:the effect of oxidation conditions on chemical and crystal structures of the water-insoluble fractions[J].Biomacromolecules,2004,5(5):1983-1989.
[18] 冯国涛,单志华.变性淀粉的种类及其应用研究[J].皮革化工,2005,22(3):25-29.
[19] DIAS A R G,DA ROSA ZAVAREZE E,ELIAS M C,et al.Pasting,expansion and textural properties of fermented cassava starch oxidised with sodium hypochlorite[J].Carbohydr Polym,2011,84:268-275.
[20] 周凤超,孔保华,刘骞,等.次氯酸钠氧化马铃薯粉和淀粉的机理及应用探究[J].食品工业,2016,37(2):244-247.
[21] SANGSEETHONG K,LERTPHANICH S,SRIROTH K.Physicochemical properties of oxidized cassava starch prepared under various alkalinity levels[J].Starch-St?rke,2009,61(2):92-100.
[22] DING B,QING Y Y,CHENG J,et al.TEMPO-mediated selective oxidation of substituted polysaccharides:an efficient approach for the determination of the degree of substitution at C-6[J].Carbohydr Res,2008,343(18):3112-3116.
[23] COSENZA V A,NAVARRO D A,PUJOL C A,et al.Partial and total C-6 oxidation of gelling carrageenans:modulation of the antiviral activity with the anionic character[J].Carbohydr Polym,2015,128:199-206.
[24] 李一鸣,张岩,曹云峰,等.壳聚糖 C6 位选择性氧化的研究进展[J].纤维素科学与技术,2012,20(2):76-81.
[25] DE NOOY A,BESEMER A,VAN BEKKUM H.Highly selective TEMPO mediated oxidation of primary alcohol groups in polysaccharides[J].Recueil des Travaux Chimiques des Pays-Bas,1994,113(3):165-166.
[26] CHANG P S,ROBYT J F.Oxidation of primary alcohol groups of naturally occurring polysaccharides with 2,2,6,6-tetramethyl-1-piperidine oxoammonium ion[J].J Carbohydr Chem,1996,15(7):819-830.
[27] 黄小雷,刘文,刘群华,等.过氧化氢氧化纤维素的研究[J].中国造纸,2015,34(11):18-21.
[28] ZHANG Y,WANG X,ZHAO G,et al.Preparation and properties of oxidized starch with high degree of oxidation[J].Carbohydr Polym,2012,87:2554-2562.
[29] SANGSEETHONG K,TERMVEJSAYANON N,SRIROTH K.Characterization of physicochemical properties of hypochlorite-and peroxide-oxidized cassava starches[J].Carbohydr Polym,2010,82:446-453.
[30] ZHOU Y,LI X,LV Y,et al.Effect of oxidation level on the inclusion capacity and solution stability of oxidized amylose in aqueous solution[J].Carbohydr Polym,2016,138:41-48.
[31] 贺丽蓉,李宏利,张凯,等.双醛淀粉的制备及其提高胶原的热稳定性研究[J].中国皮革,2009,38(15):23-27.
[32] LI D,YE Y,LI D,et al.Biological properties of dialdehyde carboxymethyl cellulose crosslinked gelatin-PEG composite hydrogel fibers for wound dressings[J].Carbohydr Polym,2016,137:508-514.
[33] ZHANG X,YANG Y,YAO J,et al.Strong collagen hydrogels by oxidized dextran modification[J].ACS Sustainable Chem Eng,2014,2(5):1318-1324.
[34] DAWLEE S,SUGANDHI A,BALAKRISHNAN B,et al.Oxidized chondroitin sulfate-cross-linked gelatin matrixes:a new class of hydrogels[J].Biomacromolecules,2005,6(4):2040-2048.
[35] 冯玉杰,卢伟,岩小丽,等.双醛普鲁兰改性胶原支架材料的制备与表征[J].中外医疗,2010,29(21):10-12.
[36] MU C,LIU F,CHENG Q,et al.Collagen cryogel cross-linked by dialdehyde starch[J].Macromol Mater Eng,2010,295(2):100-107.
[37] TAN H,WU B,LI C,et al.Collagen cryogel cross-linked by naturally derived dialdehyde carboxymethyl cellulose[J].Carbohydr Polym,2015,129:17-24.
[38] YE Y,ZHU M,MIAO K,et al.Development of antimicrobial gelatin-based edible films by incorporation of trans-anethole/β-cyclodextrin inclusion complex[J].Food Bioprocess Tech,2017,10:1844-1853.
[39] ZHOU Y,YE Y,ZHANG W,et al.Oxidized amylose with high carboxyl content:a promising solubilizer and carrier of linalool for antimicrobial activity[J].Carbohyd Polym,2016,154:13-19.
[40] LYU Y,REN H,YU M,et al.Using oxidized amylose as carrier of linalool for the development of antibacterial wound dressing[J].Carbohydr Polym,2017,174:1095-1105.
[41] 杜简心,马健,朱江.长链烷基疏水改性双醛淀粉的制备优化研究[J].重庆文理学院学报,2016,35(5):79-83.
[42] WALI A R M,ZHOU J,MA S,et al.Tailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems[J].Int J Pharm,2017,525(1):191-202.
[43] DINEEN P.The effect of oxidized regenerated cellulose on experimental infected splenotomies[J].J Surg Res,1977,23(2):114-116.
[44] 贺金梅,王凤文,张华威,等.医用可吸收止血材料的功能化改性研究进展[J].现代化工,2010,30(12):11-15.
[45] SPANGLER D,ROTHENBURGER S,NGUYEN K,et al.In vitro antimicrobial activity of oxidized regenerated cellulose against antibiotic-resistant microorganisms[J].Surg Infect,2003,4(3):255-262.
[46] JAYAKUMAR G C,KANTH S V,CHANDRASEKARAN B,et al.Preparation and antimicrobial activity of scleraldehyde from Schizophyllum commune[J].Carbohydr Res,2010,345(15):2213-2219.
[47] ZHU M,GE L,LYU Y,et al.Preparation,characterization and antibacterial activity of oxidized κ-carrageenan[J].Carbohydr Polym,2017,174:1051-1058.

备注/Memo

备注/Memo:
收稿日期:2017-07-21修回日期:2017-09-24
基金项目:国家自然科学基金(21206098、21276166); 四川大学优秀青年学者科研基金(2015SCU04A34)
作者简介:訾娅鑫(1994—),女,内蒙古达拉特旗人,硕士研究生,研究方向:生物化工; 李德富(联系人),副教授,E-mail:lidefu@scu.edu.cn; 穆畅道(联系人),教授,E-mail:cdmu@scu.edu.cn
引文格式:訾娅鑫,雷金凤,徐志朗,等.多糖的氧化改性及在生物医药领域的应用[J].生物加工过程,2018,16(1):31-37.
ZI Yaxin,LEI Jinfeng,XU Zhilang,et al.Preparation and biomedical applications of oxidized polysaccharides[J].Chin J Bioprocess Eng,2018,16(1):31-37..
更新日期/Last Update: 2018-01-30